Introduction: Carney Complex is an autosomal dominant syndrome that is defined with different tumors including myxoma in different organs, endocrine tumors and lentiginosis lesions. This is the first case report of this syndrome from Iran.Case: The patient is a 27 year old girl, referred with flank pain. Physical examination revealed hirsutism, truncal obesity, hyperpigmantasion and hypertension; Cushing's syndrome was suggested and confirmed with related classic biochemical tests. She had history of cardiac myxoma during her childhood and had been operated twice.Pituitary microadenoma and right adrenal adenoma were reported on MRI and CT-scan, respectively. Initially laparascopic right adrenalectomy was done; as expected, no remission in signs of Cushing's syndrome was observed after surgery. By laparoscopic adrenalectomy of the other site, Cushing's syndrome resolved. Pathologic report of 1st operation was adrenal adenoma with surrounding pigmented micronodular hyperplasia and of the 2nd one was just pigmented micronodular hyperplasia.Conclusion: We have reported a patient with Carney syndrome along with Cushing's syndrome due to bilateral adrenal hyperplasia and an adenoma in contralateral adrenal and microadenoma of the pituitary as an incidentaloma. This is a new presentation of Carney syndrome.

Free vibrations of the cylindrical-hemispherical shell made of functionally graded porous materials with variable thickness are investigated in the cylindrical coordinate system. In this study, two boundary conditions is examined. The first B.C is assumed free-free and second B.C is considered clamped-free in cylindrical and hemispherical, respectively. The present analysis is based on three-dimensional elasticity relations and the Ritz method, using orthogonal polynomials such as Legendre as admissible functions. Convergence of results for natural frequencies is shown. The results were compared with the previous results of the finite element method and analytical studies. After confirming the accuracy of the results by adding the porosity effect, its effect on the frequency of the hemispherical-cylindrical shell was investigated. The results show that the shell frequency decreased with an increase in the porosity coefficient. Natural frequencies were obtained with different geometric parameters. Finally, the results show that the porosity coefficient and geometric parameters have a significant effect on the natural frequency of the porous Complex shells. The results show that torsional modes (n=0^T) and axisymmetric modes (n=0^A) play a more important role in clamped-free B.C compared to free-free B.C. Decreasing the thickness generally decreases the frequencies in all modes. Also, it can be seen that with the increase of the porosity coefficient in the cylindrical-hemispherical shell due to the decrease in stiffness, the frequencies decrease in all modes.

Sea shells are natural-biological objects. They are embedded in geological layers in the form of fossils, but also, to find in archaeological deposits as a result of human activities. Archaeologists can use the provenance of shells in the functional analysis of ancient sites in terms of social archeology and prehistoric trading activities. Aarcheological excavations in several sites of the Iranian Plateau have shown that from the 3rd third millennium B.C. onwards, finds of of sea shells (e.g. Lambis, Dentalium, etc.) rapidely increased. Such shells were for instance discovered from ritual cemetery contexts such as Shahdad, Tepe Hesar, Kale Nisar cemeteries or Bani Surma. These objects are mainly used as natural or polished shells. In some cases, they served as a raw material for making all kinds of beads, buttons, and other ornamental objects.. The main question is to understand the relationship between the use of seashells and archaeological context, and also, their role in Bronze Age ritual life. In this article, the descriptive, analytical method has been used in the biological recognition of all types of shells. This method is also used based on similar studies on this issue in Mesopotamia's archeology of the Sumerian-Akkadian period. The distribution of recognizable species shows that these objects are concentrated in the settlements from south to southeast of Iran in the coastal strip of the Persian Gulf, and from the Oman Sea to the Zagros intermountain valleys, as well as in the northwest and northeast of Iran. The biological origin can be placed in the northern shores of the Oman Sea to the Gulf of Kutch on the northern coast of the Indian Ocean. It seems that with the growth and development of urbanization in Southwest Asia and especially the development of sea trade, oysters have been traded as valuable goods and other prestige goods. The importance of the shell findings is more than the value of the shells themselves because they were used as sacred goods in religious affairs. Analysis of the fields where the shells were discovered is more related to cemeteries and temples as sacred spaces. Also, the significant presence of Lambis shells for the production of specific ritual bowls, placed together with bronze axes in graves, can be seen as the reflection of a patriarchic tradition in the social-political organisiation of the third and second millennia B.C. Despite many excavations and the discovery of many samples of these types of shells, no furthergoing investigation on these specific objects was undertaken so far. This desideratum reveals more valuable findings in the archeology of the Iranian plateau. Therefore, one of this article's final goals is to focus more on analyzing the context of the discovery of seashells in future Excavation

Introduction: Men with unexplained infertility and azoospermia are often observed in the context of genetic defects. The expression of a wide variety of genes is developmentally regulated  during human meiosis. Synaptonemal Protein 3 (SYCP3) gene, located on chromosome 12, encodes a DNA-binding protein as the structural component of the synaptonemal Complex,which mediates the synopsis or homologous pairing of chromosomes during meiosis. Absence of SYCP3 in mice may lead to male infertility as well as female sub-fertility. SYCP3 expression analysis could be a tool for the prediction of human spermatogenesis progression, especially in infertile men.Materials & Methods: SYCP3 mRNA expression in testicular samples of 110 patients with non-obstructive azoospermia were studied in Avesina Infertility Clinic in Tehran, Iran during 2005 and early 2006. Semi-quantitative nested reverse transcriptase-PCR was employed in order to find the strength of gene expression. Using histopathological scoring for all samples, the expression level of SYCP3 during spermatogenesis was also evaluated.Results: Testicular SYCP3 mRNA expression was observed in 67 patients (60.9%). The expression level correlated with the degree of spermatogenic failure (p<0.0001). While this gene had been expressed in patients with hypo-spermatogenesis and maturation arrest, a lack of expression was seen in those with spermatogonial arrest, Sertoli cell-only syndrome and testicular atrophy.Conclusion: These data indicate that SYCP3 is expressed in the human testis and it is restricted to germ cells. Our findings, in association with those obtained in experimental animals, show that lack of SYCP3 expression may have negative effects on spermatogenesis and male fertility. SYCP3 gene expression may help detect specific spermatogenesis stages in conjunction with histopathological findings.

Shell structures have various applications in Civil and Mechanical engineering. shells, like other types of structure, are subject to damage and deterioration, such as development and propagation of cracks. In this research, the effect of a full penetration non - propagating macro crack, with various parameters, on natural vibration frequencies and mode shapes, is investigated. For this purpose, 400 cracked shell models have been created. These shells are grouped into cylindrical panels and full cylindrical shells and the effect of various parameters, such as crack length, crack orientation, thickness, poison ratio, shell height and panel's central angle, on the vibration frequencies and mode shapes of the shells, has been investigated.

In this paper, 2D boundary element stress analysis is carried out to obtain the T-stress for multiple internal edge cracks in thick-walled cylinders for a wide range of cylinder radius ratios and relative crack depth. The T-stress, together with the stress intensity factor K, provides a more reliable two-parameter prediction of fracture in linear elastic fracture mechanics. T-stress weight functions are then derived from the T-stress solutions for two reference load conditions corresponding to the cases when the cracked cylinder is subject to a uniform and to a linear applied stress variation on the crack faces. The derived weight functions are then verified for several non-linear load conditions. Using the BEM results as reference T-stress solutions; the T-stress weight functions for thick-walled cylinder have also been derived. Excellent agreements between the BEM results and weight function predictions are obtained. The weight functions derived are suitable for obtaining Tstress solutions for the corresponding cracked thick-walled cylinder under any Complex stress fields. Results of the study show that the two dimensional BEM analysis, together with weight function method, can be used to provide a quick and accurate estimate of T-stress for 2-D crack problems.